Report of the British Nutrition Foundation's Task Force. Unsaturated fatty acids: Nutritional and physiological significance. London: Chapman & Hall, 1992.

3.2 EPA y DHA y muerte s�bita

Brouwer IA, Zock PL, Camm AJ, B�cker D, Hauer RN, Wever EF, Dullemeijer C, Ronden JE, Katan MB, Lubinski A, Buschler H, Schouten EG; SOFA Study Group. Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. JAMA. 2006;295(22):2613-9.

Burr ML, Fehily AM, Gilbert JF, y cols. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART). Lancet 1989; 2: 757-61.

Connolly SJ, Healey JS. Omega-3 fatty acids and sudden arrhythmic death. Herz. 2006 Dec;31 Suppl 3:59-64.

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell�Infarto miocardico. Lancet 1999;354:447-55.

Kottke TE, Wu LA, Brekke LN, Brekke MJ, White RD. Preventing sudden death with n-3 (omega-3) fatty acids and defibrillators. Am J Prev Med. 2006 Oct;31(4):316-323.

Leaf A, Albert CM, Josephson M, Steinhaus D, Kluger J, Kang JX, Cox B, Zhang H, Schoenfeld D; Fatty Acid Antiarrhythmia Trial Investigators. Prevention of fatal arrhythmias in high-risk sub- jects by fish oil n-3 fatty acid intake. Circulation 2005;112(18):2762-8.

Lee KW, Hamaad A, MacFadyen RJ, Lip GY .Effects of dietary fat intake in sudden death: reduction of death with omega-3 fatty acids. Curr Cardiol Rep. 2004 Sep;6(5):371-8.

Lee KW, Lip GYH. The role of omega-3-fatty acids in the secondary prevention of cardiovascular disease. QJM 2003;96:465-80.

Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB. Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation 2005;112(13):1945-52.

Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS. Fish intake and risk of incident atrial fibrillation. Circulation. 2004;110(4):368-73.

Mozaffarian D, Wu JH. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011 Nov 8;58(20):2047-67.

Nair SS, Leitch JW, Falconer J, Garg ML. Prevention of cardiac arrhythmia by dietary (n-3) polyunsaturated fatty acids and their mechanism of action. J Nutr. 1997;127(3):383-93.

O'Keefe JH Jr, Abuissa H, Sastre A, y cols. Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. Am J Cardiol 2006; 97(8): 1127-30.

Rauch B, Schiele R, Schneider S, Gohlke H, Diller F, Gottwik M, Steinbeck G, Heer T, Katus H, Zimmer R, Erdogan A, Pfafferott C, Senges J; Omega-Study Group. Highly purified omega-3 fatty acids for secondary prevention of sudden cardiac death after myocardial infarction-aims and methods of the OMEGA-study. Cardiovasc Drugs Ther. 2006 Oct;20(5):365-75.

Richter WO. Long-chain omega-3 fatty acids from fish reduce sudden cardiac death in patients with coronary heart disease. Eur J Med Res. 2003 Aug 20;8(8):332-6.

Scorza FA, Cysneiros RM, Arida RM, Terra-Bustamante VC, de Albuquerque M, Cavalheiro EA. The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy. Epilepsy Behav. 2008 Aug;13(2):279-83.

Taha AY, Ciobanu FA, Saxena A, McIntyre Burnham W. Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy. Epilepsy Behav. 2009 Jan;14(1):27-31. Epub 2008 Dec 2.

Zhao YT, Chen Q, Sun YX, Li XB, Zhang P, Xu Y, Guo JH. Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Ann Med. 2009;41(4):301-10.

Zipes DP, Camm AJ, Borggrefe M, et al. American College of Cardiology/American Heart Association Task Force; European Society of Cardiology Committee for Practice Guidelines; European Heart Rhythm Association and the Heart Rhythm Society. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death-executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Eur Heart J 2006; 27(17): 2099-140.

3.3 EPA y DHA y l�pidos plasm�ticos

Adler AJ, Holub BJ: Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentration in hypercholesterolemic men. Am J Clin Nutr. 1997;65:445-50.

Caballero R, G�mez R, N��ez L. Farmacolog�a de los �cidos grasos omega-3. Rev Esp Cardiol Supl. 2006;6:3D-19D.

Calder PC. n-3 Fatty acids and cardiovascular disease: Evidence explained and mechanisms explored. Clin Sci (Lond). 2004;107:1-11.

Cobiac L, Clifton PM, Abbey M, Belling GB, Nestel PJ. Lipid, lipoprotein, and hemostatic effects of fish vsfish-oil n-3 fatty acids in midly hyperlipidemic males. Am J Clin Nutr. 1991;53:1210-16.

Kris-Etherton PM, Harris WS, Appel LJ; American Heart Association. Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106:2747-57.

Layne KS, Goh YK, Jumpsen JA, Ryan EA, Chow P, Clandinin MT. Normal subjects consuming physiological levels of 18:3(n-3) and 20:5(n-3) from flaxseed or fish oils have characteristic differences in plasma lipid and lipoprotein fatty acid levels. J Nutr. 1996;266:2130-40.

Report of the British Nutrition Foundation's Task Force: n-3 fatty acids and health. The British Nutrition Foundation. New York & London: Chapman & Hall, 1999.64:215-21.

Seo T, Blazer WS, Deckelbaum RJ. Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr Opin Lipidol 2005; 16: 11-18.

The British Nutrition Foundation: Diet and heart disease, a round table of factors. 2nd Ed. London: Chapman & Hall, 1997.

Visioli F, Rise P, Plasmati E, Pazzucconi F, Sirtori CR, Galli C: Very low intakes of n-3 fatty acids incorporated into bovine milk reduce plasma triacylglycerol and increase HDL-cholesterol concentrations in healthy subjects. Pharmacol Res 2000; 41: 571-576.

Williams CM, Moore F, Morgan L, Wright J. Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects. Br J Nutr. 1992;68:655-66.

Zampelas A, Roche H, Knapper JM y cols. Differences in postprandial lipemic response between Northern and Southern Europeans. Atherosclerosis.1998;139:83-93.

3.4 EPA y DHA y agregaci�n plaquetaria

Kaminski WE, Jendraschak E, Kiefl R, von Schacky C. Dietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells. Blood. 1993 Apr 1;81(7):1871-9.

Malyszko JS, Malyszko J, Pawlak K, Mysliwiec M. Effect of treating glomerulonephritis with omega 3 fatty acids for selected parameters of hemostasis, blood platelet function and lipid metabolism. Przegl Lek. 1996;53(8):600-3.

Phang M, Garg ML, Sinclair AJ. Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific-Redefining platelet response to fish oils. Prostaglandins Leukot Essent Fatty Acids. 2009 Jul;81(1):35-40.

Schoene NW. Vitamin E and omega-3 fatty acids: effectors of platelet responsiveness. Nutrition. 2001 Oct;17(10):793-6.

3.5 EPA y DHA y arteriosclerosis

Garc�a-R�os A, Meneses ME, P�rez-Mart�nez P, P�rez-Jim�nez F. Omega-3 and cardiovascular disease: beyond the risk factors. Nutr Clin Diet Hosp. 2009;29(1):4-16.