Studies

Oncology

Wei Z, Wang W, Chen J, Yang D, Yan R, Cai Q. A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors. Nutr J. 2014 Mar 24;13:25. FULL TEXT

Balkwill FR, Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol. 2012 Feb;22(1):33-40.

Sethi G, Shanmugam MK, Ramachandran L et al. Multifaceted link between cancer and inflammation. Biosci Rep. 2012 Feb;32(1):1-15. FULL TEXT

Kamp DW, Shacter E, Weitzman SA. Chronic inflammation and cancer: the role of the mitochondria. Oncology (Williston Park). 2011 Apr 30;25(5):400-10, 413. FULL TEXT

Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007;26:535-51.

Chen YQ, Berquin IM, Daniel LW, Edwards IJ, O'Flaherty JT, Thomas MJ, Tooze JA, Wykle B. Omega-3 fatty acids and cancer risk. JAMA. 2006;296:282.

Pratt VC, Watanabe S, Bruera E, et al. Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation. Br J Cancer. 2002;87:1370-8. FULL TEXT

Mataix J, Gil A. Libro blanco de los Omega-3: los ácidos grasos poliinsaturados omega 3 y monoinsaturados tipo oleico y su papel en la salud. Madrid: Puleva Food. Panamericana, 2002. FULL TEXT

Das U, Madhavi G, Kumar G, Padma M, Sangeetha P. Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? Prostaglandins Leukot Essent Fatty Acids. 1998;58:39-54.

Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer. 1998;82:395-402.

Sargent JR. Fish oils and human diet. Br J Nutr. 1997;78:S5-S13.

Jump DB, Clarke SD, Thelen A, Liimatta M, Ren B, Badin MV. Dietary fat, genes and human health. Med Biol 1997;422:167-76.

Prevention

Finch ER, Kudva AK, Quickel MD, Goodfield LL, Kennett MJ, Whelan J, Paulson RF, Prabhu KS. Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia. Cancer Prev Res (Phila). 2015 Oct;8(10):989-99.

Fabian CJ, Kimler BF, Phillips TA, Nydegger JL, Kreutzjans AL, Carlson SE, Hidaka BH, Metheny T, Zalles CM, Mills GB, Powers KR, Sullivan DK, Petroff BK, Hensing WL, Fridley BL, Hursting SD. Modulation of Breast Cancer Risk Biomarkers by High Dose Omega-3 Fatty Acids: Phase II Pilot Study in Post-menopausal Women. Cancer Prev Res (Phila). 2015 Aug 14. pii: canprevres.0336.2014.

Vara-Messler M, Buccellati C, Pustina L, Folco G, Rovati GE, Hoxha M. A potential role of PUFAs and COXIBs in cancer chemoprevention. Prostaglandins Other Lipid Mediat. 2015 Apr 20. pii: S1098-8823(15)00045-3.

Pradhan AD, Manson JE. Update on the Vitamin D and OmegA-3 trial (VITAL). J Steroid Biochem Mol Biol. 2015 Apr 9. pii: S0960-0760(15)00103-X. doi: 10.1016/j.jsbmb.2015.04.006.

Terry PD, Rohan TE, Wolk A. Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. Am J Clin Nutr. 2003;77:532-43. FULL TEXT

MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC. Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA. 2006;295:403-15.

Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Dietary long chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 2004; 79: 935-45. FULL TEXT

Treatment

Ferguson LR. Fish oils in parenteral nutrition: Why could these be important for gastrointestinal oncology? World J Gastrointest Oncol. 2015 Sep 15;7(9):128-31. FULL TEXT

So WW, Liu WN, Leung KN. Omega-3 Polyunsaturated Fatty Acids Trigger Cell Cycle Arrest and Induce Apoptosis in Human Neuroblastoma LA-N-1 Cells. Nutrients. 2015 Aug 18;7(8):6956-6973. FULL TEXT

Murakami K, Miyata H, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y. ω-3 Fatty Acids Reduce Chemotherapy-Induced Hematological Toxicity by Bone Marrow Stimulation in Mice. JPEN J Parenter Enteral Nutr. 2015 Jul 28. pii: 0148607115597887.

de Aguiar Pastore Silva J, Emilia de Souza Fabre M, Waitzberg DL. Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review. Clin Nutr. 2015 Jun;34(3):359-66. doi: 10.1016/j.clnu.2014.11.005.

Murray M, Hraiki A, Bebawy M, Pazderka C, Rawling T. Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs. Pharmacol Ther. 2015 Jun;150:109-28. doi: 10.1016/j.pharmthera.2015.01.008.

Daenen LG, Cirkel GA, Houthuijzen JM, Gerrits J, Oosterom I, Roodhart JM, van Tinteren H, Ishihara K, Huitema AD, Verhoeven-Duif NM, Voest EE. Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil. JAMA Oncol. 2015 Jun 1;1(3):350-8.

Vara-Messler M, Buccellati C, Pustina L, Folco G, Rovati GE, Hoxha M. A potential role of PUFAs and COXIBs in cancer chemoprevention. Prostaglandins Other Lipid Mediat. 2015 Apr 20. pii: S1098-8823(15)00045-3. doi: 10.1016/j.prostaglandins.

Xue H, Ren W, Denkinger M, Schlotzer E, Wischmeyer PE. Nutrition Modulation of Cardiotoxicity and Anticancer Efficacy Related to Doxorubicin Chemotherapy by Glutamine and ω-3 Polyunsaturated Fatty Acids. JPEN J Parenter Enteral Nutr. 2015 Apr 17. pii: 0148607115581838.

Abdi J, Garssen J, Faber J, Redegeld FA. Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells. J Nutr Biochem. 2014 Dec;25(12):1254-62. doi: 10.1016/j.jnutbio.2014.06.013.

Zhang G, Panigrahy D, Mahakian LM et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6530-5. FULL TEXT

Merendino N, Costantini L, Manzi L et al. Dietary ? -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int. 2013;2013:310186. FULL TEXT

Berquin, I, Edwards IJ, Chen YQ. Multi-targeted Therapy of Cancer by Omega-3 Fatty Acids. Cancer Lett. 2008;269(2):363-77. FULL TEXT

Anorexia and cachexia associated with cancer

Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K. Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol. 2015 Apr 15;7(4):17-29. doi: 10.4251/wjgo.v7.i4.17. FULL TEXT

Pappalardo G, Almeida A, Ravasco P. Eicosapentaenoic acid in cancer improves body composition and modulates metabolism. Nutrition. 2015 Apr;31(4):549-55. doi: 10.1016/j.nut.2014.12.002.

Bruera E, Strasser F, Palmer JL, Willey J, Calder K, Amyotte G, Baracos V. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a doubleblind, placebo-controlled study. J Clin Oncol. 2003;21:129-34. FULL TEXT

Kanat O, Cubukcu E, Avci N et al. Comparison of three different treatment modalities in the management of cancer cachexia. Tumori 2013;99(2):229-233.

Mantovani G, Maccio A, Madeddu C, Gramignano G, Lusso MR, Serpe R, Massa E, Astara G, Deiana L. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prev. 2006;15:1030-4. FULL TEXT

Harle L, Brown T, Laheru D, Dobs AS. Omega-3 fatty acids for the treatment of cancer cachexia: issues in designing clinical trials of dietary supplements. J Altern Complement Med. 2005;11:1039-46.

Jatoi A, Rowland K, Loprinzi CL, Sloan JA, Dakhil SR, MacDonald N, Gagnon B, Novotny PJ, Mailliard JA, Bushey TI, Nair S, Christensen B; North Central Cancer Treatment Group. An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada collaborative effort. J Clin Oncol 2004;22:2469-2476. FULL TEXT

Burns CP, Halabi S, Clamon G, Kaplan E, Hohl RJ, Atkins JN, Schwartz MA, Wagner BA, Paskett E. Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia. Cancer. 2004;101:370-8. FULL TEXT

Fearon KC, Von Meyenfeldt MF, Moses AG, Van Geenen R, Roy A, Gouma DJ, Giacosa A, Van Gossum A, Bauer J, Barber MD, Aaronson NK, Voss AC, Tisdale MJ. Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut. 2003;52:1479-86. FULL TEXT

Burns CP, Halabi S, Clamon GH, Hars V, Wagner BA, Hohl RJ, Lester E, Kirshner JJ, Vinciguerra V, Paskett E. Phase I clinical study of fish oil fatty acid capsules for patients with cancer cachexia: cancer and leukemia group B study 9473. Clin Cancer Res. 1999;5:3942-7. FULL TEXT

Bladder cancer

Breast cancer

Mansara P, Ketkar M, Deshpande R, Chaudhary A, Shinde K, Kaul-Ghanekar R. Improved antioxidant status by omega-3 fatty acid supplementation in breast cancer patients undergoing chemotherapy: a case series. J Med Case Rep. 2015 Jun 24;9:148. FULL TEXT

Rovito D, Giordano C, Plastina P, Barone I, De Amicis F, Mauro L, Rizza P, Lanzino M, Catalano S, Bonofiglio D, Andò S. Omega-3 DHA- and EPA-dopamine conjugates induce PPARγ-dependent breast cancer cell death through autophagy and apoptosis. Biochim Biophys Acta. 2015 Nov;1850(11):2185-95.

Rescigno T, Capasso A, Tecce MF. Effect of docosahexaenoic acid on cell cycle pathways in breast cell lines with different transformation degree. J Cell Physiol. 2015 Oct 19. doi: 10.1002/jcp.25217.

Fabian CJ, Kimler BF, Phillips TA, Box JA, Kreutzjans AL, Carlson SE, Hidaka BH, Metheny T, Zalles CM, Mills GB, Powers KR, Sullivan DK, Petroff BK, Hensing WL, Fridley BL, Hursting SD. Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women. Cancer Prev Res (Phila). 2015 Oct;8(10):912-21.

Straka S, Lester JL, Cole RM, Andridge RR, Puchala S, Rose AM, Clinton SK, Belury MA, Yee LD. Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: A randomized clinical trial of dietary fish and n-3 fatty acid capsules. Mol Nutr Food Res. 2015 Sep;59(9):1780-90.

Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul;34(27):3504-13. doi: 10.1038/onc.2014.283.

Ford NA, Rossi EL, Barnett K, Yang P, Bowers LW, Hidaka BH, Kimler BF, Carlson SE, Shureiqi I, deGraffenried LA, Fabian CJ, Hursting SD. Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-like and Claudin-Low Breast Cancer. Cancer Prev Res (Phila). 2015 Sep;8(9):796-806.

Fabian CJ, Kimler BF, Hursting SD. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015 May 4;17(1):62. doi: 10.1186/s13058-015-0571-6. FULL TEXT

Fabian CJ, Kimler BF, Hursting SD. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015 May 4;17(1):62. doi: 10.1186/s13058-015-0571-6. FULL TEXT

Wu S, Guo Y, Wu Y, Zhu S, He Z, Chen YQ. Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis. Biochem Biophys Res Commun. 2015 Apr 3;459(2):294-9. doi: 10.1016/j.bbrc.2015.02.103. FULL TEXT

Wu S, Guo Y, Wu Y, Zhu S, He Z, Chen YQ. Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis. Biochem Biophys Res Commun. 2015 Apr 3;459(2):294-9. doi: 10.1016/j.bbrc.2015.02.103.

Khankari NK, Bradshaw PT, Steck SE, He K, Olshan AF, Shen J, Ahn J, Chen Y, Ahsan H, Terry MB, Teitelbaum SL, Neugut AI, Santella RM, Gammon MD. Dietary intake of fish, polyunsaturated fatty acids, and survival after breast cancer: A population-based follow-up study on Long Island, New York. Cancer. 2015 Mar 24. doi: 10.1002/cncr.29329.

Hidaka BH, Li S, Harvey KE, Carlson SE, Sullivan DK, Kimler BF, Zalles CM, Fabian CJ. Omega-3 and Omega-6 Fatty Acids in Blood and Breast Tissue of High-Risk Women and Association with Atypical Cytomorphology. Cancer Prev Res (Phila). 2015 Feb 23. pii: canprevres.0351.2014.

Lorgeril M, Salen P. Helping women to good health: breast cancer, omega-3/omega-6 lipids, and related lifestyle factors. BMC Medicine. 2014;12:54. FULL TEXT

Manni A, Richie JP Jr, Xu H et al. Influence of omega-3 fatty acids on Tamoxifen-induced suppression of rat mammary carcinogenesis. Int J Cancer. 2013 Sep 30.

Zheng JS, Hu XJ, Zhao YM, Yang J, Li D. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ. 2013 Jun 27;346:f3706. FULL TEXT

Cao W, Ma Z, Rasenick MM et al. N-3 poly-unsaturated fatty acids shift estrogen signaling to inhibit human breast cancer cell growth. PLoS One. 2012;7(12):e52838. FULL TEXT

Cao W, Ma Z, Rasenick MM et al. N-3 poly-unsaturated fatty acids shift estrogen signaling to inhibit human breast cancer cell growth. PLoS One. 2012;7(12):e52838. FULL TEXT

Alfano CM, Imayama I, Neuhouser ML, Kiecolt-Glaser JK, Smith AW, Meeske K, McTiernan A, Bernstein L, Baumgartner KB, Ulrich CM, Ballard-Barbash R. Fatigue, Inflammation, and ?-3 and ?-6 Fatty Acid Intake Among Breast Cancer Survivors. JCO. 2012. doi: 10.1200/JCO.2011.36.4109 FULL TEXT

Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, Clinton SK. Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition. Am J Clin Nutr. 2010 May;91(5):1185-94. FULL TEXT

Dimri M, Bommi PV, Sahasrabuddhe AA, Khandekar JD, Dimri GP. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. Carcinogenesis. 2010 Mar;31(3):489-95. FULL TEXT

Altenburg JD, Siddiqui RA. Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells. Mol Cancer Res. 2009 Jul;7(7):1013-20. FULL TEXT

Kim J, Lim SY, Shin A, Sung MK, Ro J, Kang HS, Lee KS, Kim SW, Lee ES. Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study. BMC Cancer. 2009 Jun 30;9:216. FULL TEXT

Thiébaut AC, Chajès V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, Berrino F, Riboli E, Bénichou J, Clavel-Chapelon F. Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. Int J Cancer. 2009 Feb 15;124(4):924-31. FULL TEXT

Hammamieh R, Chakraborty N, Miller SA, Waddy E, Barmada M, Das R, Peel SA, Day AA, Jett M. Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16.

Menéndez JA, Vázquez-Martín A, Ropero S, Colomer R, Lupu R. HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail". Clin Transl Oncol. 2006 Nov;8(11):812-20.

Isbilen B, Fraser SP, Djamgoz MB. Docosahexaenoic acid (omega-3) blocks voltage-gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells. Int J Biochem Cell Biol. 2006;38(12):2173-82.

Bougnoux P, Hajjaju N, Baucher MA, Jordan ML, Goupille C, Body G, LeFoch O. Docosahexaenoic acid (DHA) intake during first line chemotherapy improves survival in metastatic breast cancer. Proc Am Assoc Cancer Res. 2006;47:1237. FULL TEXT

Wu M, Harvey KA, Ruzmetov N, Welch ZR, Sech L, Jackson K, Stillwell W, Zaloga GP, Siddiqui RA. Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway. Int J Cancer. 2005 Nov 10;117(3):340-8. FULL TEXT

Barascu A, Besson P, Le Floch O, Bougnoux P, Jourdan ML. CDK1-cyclin B1 mediates the inhibition of proliferation induced by omega-3 fatty acids in MDA-MB-231 breast cancer cells. Int J Biochem Cell Biol. 2006 Feb;38(2):196-208. Epub 2005 Sep 15.

Schley PD, Jijon HB, Robinson LE, Field CJ. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat. 2005 Jul;92(2):187-95.

Menendez JA, Lupu R, Colomer R. Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. Eur J Cancer Prev. 2005 Jun;14(3):263-70.

Sun H, Berquin IM, Edwards IJ. Omega-3 polyunsaturated fatty acids regulate syndecan-1 expression in human breast cancer cells. Cancer Res. 2005 May 15;65(10):4442-7. FULL TEXT

Menéndez JA, Ropero S, Mehmi I, Atlas E, Colomer R, Lupu R. Overexpression and hyperactivity of breast cancer- ssociated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acia novel mechanism by which dietary fat can alter mammary tumorigenesis. Int J Oncol 2004; 24: 1369-83).

Goodstine SL, Zheng T, Holford TR, Ward BA, Carter D, Owens PH, Mayne ST. Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not to post-menopausal breast cancer risk in US women. J Nutr. 2003;133:1409-14. FULL TEXT

Goodstine SL, Zheng T, Holford TR, Ward BA, Carter D, Owens PH, Mayne ST. Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not to post-menopausal breast cancer risk in US women. J Nutr. 2003;133:1409-14. FULL TEXT

Maillard V, Bougnoux P, Ferrari P, Jourdan ML, Pinault M, Lavillonnière F, Body G, Le Floch O, Chajès V.. n-3 and n-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int J Cancer. 2002;98:78-83. FULL TEXT

Stoll BA. n-3 fatty acids and lipid peroxidation in breast cancer inhibition. Br J Nutr 2002; 87:193-198.

Moore NG, Wang-Johanning F, Chang PL, Johanning GL. Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells. Breast Cancer Res Treat. 2001 Jun;67(3):279-83.

Wang M, Liu YE, Ni J, Aygun B, Goldberg ID, Shi YE. Induction of mammary differentiation by mammary-derived growth inhibitor-related gene that interacts with an omega-3 fatty acid on growth inhibition of breast cancer cells. Cancer Res. 2000 Nov 15;60(22):6482-7. FULL TEXT

Bartsch H, Nair J, Owen RW. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 1999; 20: 2209-18. FULL TEXT

Bartsch H, Nair J, Owen RW. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 1999; 20: 2209-18. FULL TEXT

Bougnoux P, Germain E, Chajès V, Hubert B, Lhuillery C, Le Floch O, Body G, Calais G. Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acidlevel in locally advanced breast carcinoma. Br J Cancer. 1999;79:1765-9. FULL TEXT

Blog

Siguel EN. Re: Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer. J Natl Cancer Inst. 1998 Apr 15;90(8):629-31 FULL TEXT

Simonsen N, van't Veer P, Strain JJ, Martin-Moreno JM, Huttunen JK, Navajas JF, Martin BC, Thamm M, Kardinaal AF, Kok FJ, Kohlmeier L. Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Am J Epidemiol. 1998 Feb 15;147(4):342-52. FULL TEXT

Platet N, Prevostel C, Derocq D, Joubert D, Rochefort H, García M. Breast cancer cell invasiveness: correlation with PKCactivity and differential regulation by phorbol ester in ER positive and negative cells. Int J Cancer. 1998; 75:750-6. FULL TEXT

Badawi AF, El-Sohemy A, Stephen LL, Ghoshai AK, Archer MC. The effect of dietary n-3 and n-6 polyunsaturated fatty acids on the expression of cyclooxygenase 1 and 2 and levels of p21 ras in rat mammary glands. Carcinogenesis. 1998;19:905-10. FULL TEXT

Bagga D, Capone S, Wang HJ, Heber D, Lill M, Chap L, Glaspy JA. Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer. J Natl Cancer Inst. 1997 Aug 6;89(15):1123-31. FULL TEXT

Bagga D, Capone S, Wang HJ, Heber D, Lill M, Chap L, Glaspy JA. Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer. J Natl Cancer Inst. 1997 Aug 6;89(15):1123-31. FULL TEXT

Rose DP, Connolly JM, Coleman M. Effect of n-3 fatty acids on the progression pf metastases after excision of human breast cancer cell solid tumors growing in nude mice. Clin Cancer Res. 1996;2:1751-6. FULL TEXT

Colon cancer

Zhang C, Yu H, Ni X, Shen S, Das UN. Growth Inhibitory Effect of Polyunsaturated Fatty Acids (PUFAs) on Colon Cancer Cells via Their Growth Inhibitory Metabolites and Fatty Acid Composition Changes. PLoS One. 2015 Apr 17;10(4):e0123256. doi: 10.1371/journal.pone.0123256. FULL TEXT

Song M, Nishihara R, Wu K, Qian ZR, Kim SA, Sukawa Y, Mima K, Inamura K, Masuda A, Yang J, Fuchs CS, Giovannucci EL, Ogino S, Chan AT. Marine ω-3 Polyunsaturated Fatty Acids and Risk of Colorectal Cancer According to Microsatellite Instability. J Natl Cancer Inst. 2015 Mar 25;107(4). pii: djv007. doi: 10.1093/jnci/djv007. FULL TEXT

Yang K, Li H, Dong J, Dong Y, Wang CZ. Expression profile of polyunsaturated fatty acids in colorectal cancer. World J Gastroenterol. 2015 Feb 28;21(8):2405-12. doi: 10.3748/wjg.v21.i8.2405. FULL TEXT

Piazzi G, D'Argenio G, Prossomariti A, Lembo V, Mazzone G, Candela M, Biagi E, Brigidi P, Vitaglione P, Fogliano V, D'Angelo L, Fazio C, Munarini A, Belluzzi A, Ceccarelli C, Chieco P, Balbi T, Loadman PM, Hull MA, Romano M, Bazzoli F, Ricciardiello L. Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota. Int J Cancer. 2014 Mar 19.

Fasano E, Serini S, Piccioni E et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta. 2012 Nov;1822(11):1762-72. FULL TEXT

Janakiram NB, Mohammed A, Rao CV. Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer. Cancer Metastasis Rev. 2011 Dec;30(3-4):507-23.

Kim S, Sandler DP, Galanko J, Martin C, Sandler RS. Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans. Am J Epidemiol. 2010;171(9):969-79. FULL TEXT

American Association for CAncer Research. Omega-3 Fatty Acids May Reduce Risk of Colon Cancer. ScienceDaily. Dec 2009.

Bathen TF, Holmgren K, Lundemo AG, Hjelstuen MH, Krokan HE, Gribbestad IS, Schønberg SA. Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice. Anticancer Res. 2008 Nov-Dec;28(6A):3717-23. FULL TEXT

Chapkin RS, McMurray DN, Lupton JR. Colon cancer, fatty acids and anti-inflammatory compounds. Curr Opin Gastroenterol 2007;23:48-54.

Bartram HP, Gostner A, Reddy BS, Rao CV, Scheppach W, Dusel G, Richter A, Richter F, Kasper H. Missing anti-proliferative effect of fish oil on rectal epithelium in healthy volunteers consuming a high-fat diet: potential role of the n-3:n-6 fatty acid ratio. Eur J Cancer Prev 1995;4:231-237.

Bartram HP, Gostner A, Scheppach W, Reddy BS, Rao CV, Dusel G, Richter F, Richter A, Kasper H. Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects. Gastroenterology. 1993;105:1317-22.

Bartoli GM, Palozza P, Marra G, Armelao F, Franceschelli P, Luberto C, Sgarlata E, Piccioni E, Anti M. n-3 PUFA and alpha-tocopherol control of tumor cell proliferation. Mol Aspects Med. 1993;14:247-52.

Liver cancer

Lung cancer

Pancreatic cancer

Prostate cancer

Allaire J, Moreel X, Labonté MÈ, Léger C, Caron A, Julien P, Lamarche B, Fradet V. Validation of the omega-3 fatty acid intake measured by a web-based food frequency questionnaire against omega-3 fatty acids in red blood cells in men with prostate cancer. Eur J Clin Nutr. 2015 Sep;69(9):1004-8.

Hu Z, Qi H, Zhang R, Zhang K, Shi Z, Chang Y, Chen L, Esmaeili M, Baniahmad A, Hong W. Docosahexaenoic acid inhibits the growth of hormone-dependent prostate cancer cells by promoting the degradation of the androgen receptor. Mol Med Rep. 2015 Sep;12(3):3769-74.

Hu Z, Qi H, Zhang R, Zhang K, Shi Z, Chang Y, Chen L, Esmaeili M, Baniahmad A, Hong W. Docosahexaenoic acid inhibits the growth of hormone-dependent prostate cancer cells by promoting the degradation of the androgen receptor. Mol Med Rep. 2015 May 21. doi: 10.3892/mmr.2015.3813.

Alexander DD, Bassett JK, Weed DL, Barrett EC, Watson H, Harris W. Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer. Nutr Cancer. 2015 May-Jun;67(4):543-54. doi: 10.1080/01635581.2015.1015745 FULL TEXT

Allaire J, Moreel X, Labonté MÈ, Léger C, Caron A, Julien P, Lamarche B, Fradet V. Validation of the omega-3 fatty acid intake measured by a web-based food frequency questionnaire against omega-3 fatty acids in red blood cells in men with prostate cancer. Eur J Clin Nutr. 2015 Mar 11. doi: 10.1038/ejcn.2015.7.

Liu Z, Hopkins MM, Zhang Z, Quisenberry CB, Fix LC, Galvan BM, Meier KE. Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells. J Pharmacol Exp Ther. 2015 Feb;352(2):380-94.

Moreel X Xm, Allaire J, Léger C, Caron A, Labonté ME, Lamarche B, Julien P, Desmeules P, Têtu B, Fradet V. Prostatic and dietary omega-3 fatty acids and prostate cancer progression during active surveillance. Cancer Prev Res (Phila). 2014 May 13. pii: canprevres.0349.2013. [Epub ahead of print] FULL TEXT

Gu Z, Suburu J, Chen H et al. Mechanisms of Omega-3 Polyunsaturated Fatty Acids in Prostate Cancer Prevention. ioMed Research International. Volume 2013 (2013), Article ID 824563, 10 pages FULL TEXT

Fradet V, Cheng I, Casey G, Witte JS. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. Clin Cancer Res 2009; 15(7): 2559-66. FULL TEXT

Brouwer IA. Omega-3 PUFA: good or bad for prostate cancer? Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):97-9.

Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007;117(7):1866-75. FULL TEXT

Kobayashi N, Barnard RJ, Henning SM, Elashoff D, Reddy ST, Cohen P, Leung P, Hong-Gonzalez J, Freedland SJ, Said J, Gui D, Seeram NP, Popoviciu LM, Bagga D, Heber D, Glaspy JA, Aronson WJ. Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res. 2006 Aug 1;12(15):4662-70. FULL TEXT

Demark-Wahnefried W, Robertson CN, Walther PJ, Polascik TJ, Paulson DF, Vollmer RT. Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. Urology. 2004;63:900-4.

Aronson WJ, Glaspy JA, Reddy ST, Reese D, Heber D, Bagga D. Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer. Urology. 2001 Aug;58(2):283-8.

Harvei S, Bjerve KS, Tretli S, Jellum E, Robsahm TE, Vatten L. Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. Int J Cancer. 1997 May 16;71(4):545-51. FULL TEXT

Pandalai PK, Pilat MJ, Yamazaki K, Naik H, Pienta KJ. The effects of omega-3 and omega-6 fatty acids on in vitro prostate cancer growth. Anticancer Res. 1996 Mar-Apr;16(2):815-20.

Skin cancer

Uterine cancer

SUSCRÍBETE A NUESTRA NEWSLETTER