Estudios

Psiquiatría

Kim SW, Jhon M, Kim JM et al. Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study. PLoS One. 2016 Mar 10;11(3):e0151417. doi: 10.1371/journal.pone.0151417. eCollection 2016. FULL TEXT

Messamore E, McNamara RK. Detection and treatment of omega-3 fatty acid deficiency in psychiatric practice: Rationale and implementation. Lipids Health Dis. 2016 Feb 10;15(1):25. doi: 10.1186/s12944-016-0196-5. FULL TEXT

Aukema HM, Winter T, Ravandi A, Dalvi S, Miller DW, Hatch GM5. Generation of Bioactive Oxylipins from Exogenously Added Arachidonic, Eicosapentaenoic and Docosahexaenoic Acid in Primary Human Brain Microvessel Endothelial Cells. Lipids. 2015 Oct 6.

Meyer BJ, Byrne MK, Collier C, Parletta N, Crawford D, Winberg PC, Webster D, Chapman K, Thomas G, Dally J, Batterham M, Farquhar I, Martin AM, Grant L. Baseline omega-3 index correlates with aggressive and attention deficit disorder behaviours in adult prisoners. PLoS One. 2015 Mar 20;10(3):e0120220. doi: 10.1371/journal.pone.0120220. FULL TEXT

Larrieu T, Hilal LM, Fourrier C, De Smedt-Peyrusse V, Sans N, Capuron L, Layé S.Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion. Transl Psychiatry. 2014 Sep 9;4:e437. FULL TEXT

Lotrich FE, Sears B, McNamara RK. Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. J Psychosom Res. 2013 Nov;75(5):475-83. FULL TEXT

Gómez-Pinilla F, Tyagi E. Diet and cognition: interplay between cell metabolism and neuronal plasticity. Curr Opin Clin Nutr Metab Care. 2013 Sep 25. FULL TEXT

Prior PL, Galduróz JC. (N-3) Fatty acids: molecular role and clinical uses in psychiatric disorders. Adv Nutr. 2012 May 1;3(3):257-65. FULL TEXT

Sinn N, Milte C, Howe PR. Oiling the brain: a review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients. 2010 Feb;2(2):128-70. FULL TEXT

Stahl LA, Begg DP, Weisinger RS, Sinclair AJ. The role of omega-3 fatty acids in mood disorders. Curr Opin Investig Drugs. 2008 Jan;9(1):57-64.

van Strater AC, Bouvy PF. Omega-3 fatty acids and mood disorders. Am J Psychiatry. 2006 Nov;163(11):2018; author reply 2018-9

Parker G, Gibson NA, Brotchie H, Heruc G, Rees AM, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. Am J Psychiatry. 2006 Jun;163(6):969-78. Review. Erratum in: Am J Psychiatry. 2006 Oct;163(10):1842.

Ohara K. Omega-3 fatty acids in mood disorders. Seishin Shinkeigaku Zasshi. 2005;107(2):118-26.

Young C, Martin A. Omega-3 fatty acids in mood disorders: an overview. Rev Bras Psiquiatr. 2003 Sep;25(3):184-7. FULL TEXT

Zimmer L, Vancassel S, Cantagrel S, et al. The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids. Am J Clin Nutr 2002;75:662-7. FULL TEXT

Abuso de sustancias

Autismo

Demencia y Alzheimer

Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis. 2015 Oct 1;48(3):805-12.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul;29(7):2681-9.

Casali BT, Corona AW, Mariani MM, Karlo JC, Ghosal K, Landreth GE. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015 Jun 17;35(24):9173-81.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Mar 24. pii: fj.14-264218.

Shinto L, Quinn J, Montine T, Dodge HH, Woodward W, Baldauf-Wagner S, Waichunas D, Bumgarner L, Bourdette D, Silbert L, Kaye J. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis. 2014;38(1):111-20. doi: 10.3233/JAD-130722. FULL TEXT

Wiesmann M, Kiliaan AJ, Claassen JA. Vascular aspects of cognitive impairment and dementia. J Cereb Blood Flow Metab. 2013 Nov;33(11):1696-706. FULL TEXT

Zhao Y, Calon F, Julien C et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPAR?-mediated mechanisms in Alzheimer's disease models. PLoS One. 2011 Jan 5;6(1):e15816. FULL TEXT

Caballer García J. Los ácidos grasos omega-3 en la prevención de la enfermedad de Alzheimer. Alzheimer. Real Invest Demenc. 2011;49:12-18. FULL TEXT

Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA. 2010 Nov 3;304(17):1903-11. FULL TEXT

Jicha GA, Markesbery WR. Omega-3 fatty acids: potential role in the management of early Alzheimer's disease. Clin Interv Aging. 2010 Apr 7;5:45-61. FULL TEXT

Fotuhi M, Mohassel P, Yaffe K. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nat Clin Pract Neurol. 2009 Mar;5(3):140-52.

Palmblad J, Eriksdotter-Jönhagen M, Freund-Levi Y, Cederholm T. Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited. Lakartidningen. 2007 Oct 31-Nov 6;104(44):3268-71.

Depresión

Roca M, Kohls E, Gili M et al. MooDFOOD Prevention Trial Investigators. Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial. BMC Psychiatry. 2016 Jun 8;16:192. doi: 10.1186/s12888-016-0900-z. FULL TEXT

Parletta N, Zarnowiecki D, Cho J et al. People with schizophrenia and depression have a low omega-3 index. Prostaglandins Leukot Essent Fatty Acids. 2016 Jul;110:42-7. doi: 10.1016/j.plefa.2016.05.007. Epub 2016 May 13.

Khajehnasiri F, Akhondzadeh S, Mortazavi SB et al. Are Supplementation of Omega-3 and Ascorbic Acid Effective in Reducing Oxidative Stress and Depression among Depressed Shift Workers? Int J Vitam Nutr Res. 2016 May 10:1-12. [Epub ahead of print]

Bigornia SJ, Harris WS, Falcón LM et al. The Omega-3 Index Is Inversely Associated with Depressive Symptoms among Individuals with Elevated Oxidative Stress Biomarkers. J Nutr. 2016 Mar 2. pii: jn222562. [Epub ahead of print]

Carney RM, Steinmeyer BC, Freedland KE et al. Baseline blood levels of omega-3 and depression remission: a secondary analysis of data from a placebo-controlled trial of omega-3 supplements. J Clin Psychiatry. 2016 Feb;77(2):e138-43. doi: 10.4088/JCP.14m09660.

Chhetry BT, Hezghia A, Miller JM et al. Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression. J Psychiatr Res. 2016 Jan 11;75:65-74. doi: 10.1016/j.jpsychires.2015.12.007. [Epub ahead of print]

Pusceddu MM, El Aidy S, Crispie F, O'Sullivan O, Cotter P, Stanton C, Kelly P, Cryan JF, Dinan TG. N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota. PLoS One. 2015 Oct 1;10(10):e0139721. FULL TEXT

Ginty AT, Conklin SM. Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alter depression status and decrease symptomology among young adults with depression: A preliminary randomized and placebo controlled trial. Psychiatry Res. 2015 Sep 30;229(1-2):485-9.

Ginty AT, Conklin SM. Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alterdepression status and decrease symptomology among young adults with depression: Apreliminary randomized and placebo controlled trial. Psychiatry Res. 2015 Jun 27. pii: S0165-1781(15)00384-4. doi: 10.1016/j.psychres.2015.05.072. [Epub ahead of print]

Mocking RJ, Verburg HF, Westerink AM, Assies J, Vaz FM, Koeter MW, Ruhé HG, Schene AH. “Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response.” Psychoneuroendocrinology. 2015 May 11;59:1-13. doi: 10.1016/j.psyneuen.2015.04.027.

Haghighi F, Galfalvy H, Chen S, Huang YY, Cooper TB, Burke AK, Oquendo MA, Mann JJ, Sublette ME. DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk. Front Neurol. 2015 Apr 28;6:92. doi: 10.3389/fneur.2015.00092. FULL TEXT

Deacon G, Kettle C, Hayes D, Dennis C, Tucci J. Omega 3 Polyunsaturated Fatty Acids and the Treatment of Depression. Crit Rev Food Sci Nutr. 2015 Apr 1:0.

Rapaport MH, Nierenberg AA, Schettler PJ, Kinkead B, Cardoos A, Walker R, Mischoulon D. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry. 2015 Mar 24. doi: 10.1038/mp.2015.22.

Chang JP, Chang SS, Yang HT, Palani M, Chen CP, Su KP. “Polyunsaturated fatty acids (PUFAs) levels in patients with cardiovascular diseases (CVDs) with and without depression.” Brain Behav Immun. 2015 Feb;44:28-31. doi: 10.1016/j.bbi.2014.11.005.

Larrieu T, Hilal LM, Fourrier C, De Smedt-Peyrusse V, Sans N, Capuron L, Layé S. Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion. Transl Psychiatry. 2014 Sep 9;4:e437. FULL TEXT

McNamara RK, Strimpfel J, Jandacek R, Rider T, Tso P, Welge JA, Strawn JR, Delbello MP. Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder. PharmaNutrition. 2014 Apr 1;2(2):38-46. FULL TEXT

Beydoun MA, Fanelli Kuczmarski MT, Beydoun HA et al. Omega-3 fatty acid intakes are inversely related to elevated depressive symptoms among United States women. J Nutr. 2013 Sep 4. FULL TEXT

Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31(6):761-77.

Lespérance F, Frasure-Smith N, St-André E et al. The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. J Clin Psychiatry. 2011 Aug;72(8):1054-62. doi: 10.4088/JCP.10m05966blu. Epub 2010 Jun 15.

Rondanelli M, Giacosa A, Opizzi A et al. Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr. 2010 Feb;29(1):55-64.

Lin, PY, Huangb, SY, Su, KP. A Meta¬Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression Biological Psychiatry 2010;68(2):140¬147.

Mischoulon D, Papakostas GI, Dording CM, Farabaugh AH, Sonawalla SB, Agoston AM, Smith J, Beaumont EC, Dahan LE, Alpert JE, Nierenberg AA, Fava M. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J Clin Psychiatry. 2009 Dec;70(12):1636-44. Epub 2009 Aug 25. FULL TEXT

McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, Richtand NM. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the post-mortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry 2007; 62: 17-24.

Lin PY, Su, KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry. 2007;68:1056-61.

Irmish G, Schläfke D, Gierow W, Herpertz S, Richter J. Fatty acids and sleep in depressed inpatients. Prostaglandins Leuk Essent Fatty Acids. 2007;76:1-7.

Hibbein JR, Ferguson TA, Blasbalg TL. Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention. Int Rev Psychiatry. 2006;18:107-18.

Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159:477-9.

Deterioro cognitivo

Cutuli D. Functional and structural benefits induced by omega-3 polyunsaturated fatty acids during aging. Curr Neuropharmacol. 2016 Jun 13. [Epub ahead of print]

Hashimoto M, Kato S, Tanabe Y et al. Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes. Geriatr Gerontol Int. 2016 Jan 28. doi: 10.1111/ggi.12691. [Epub ahead of print]

Oulhaj A, Jernerén F, Refsum H et al. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016 Jan 6. [Epub ahead of print] FULL TEXT

Köbe T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, Pantel J, Flöel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2015 Oct 1. pii: S1053-8119(15)00872-1.

Rathod RS, Khaire AA, Kale AA, Joshi SR. Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats. Biofactors. 2015 Jul-Aug;41(4):261-72.

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.

Lorente-Cebrián S, Costa AG, Navas-Carretero S, Zabala M, Laiglesia LM, Martínez JA, Moreno-Aliaga MJ. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. J Physiol Biochem. 2015 Jun;71(2):341-9. doi: 10.1007/s13105-015-0395-y.

Pusceddu MM, Kelly P, Ariffin N, Cryan JF, Clarke G, Dinan TG. n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress. Psychoneuroendocrinology. 2015 Apr 28;58:79-90. doi: 10.1016/j.psyneuen.2015.04.015.

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Apr 15. pii: ajcn103283.

Dehkordi NG, Noorbakhshnia M, Ghaedi K, Esmaeili A, Dabaghi M. Omega-3 fatty acids prevent LPS-induced passive avoidance learning and memory and CaMKII-α gene expression impairments in hippocampus of rat. Pharmacol Rep. 2015 Apr;67(2):370-5. doi: 10.1016/j.pharep.2014.10.014.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Jul;29(7):2681-9. doi: 10.1096/fj.14-264218. Epub 2015 Mar 24.

Chang PK, Khatchadourian A, McKinney RA, Maysinger D. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology. J Neuroinflammation. 2015 Dec;12(1):244. doi: 10.1186/s12974-015-0244-5. FULL TEXT

Street SJ, Parletta N, Milte C, Sullivan K, Hills AP, Buckley J, Howe P. Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment. Aging Ment Health. 2015 Oct;19(10):885-91. doi: 10.1080/13607863.2014.971705. Epub 2014 Nov 6.

Abdel-Wahab BA, Al-Qahtani JM, El-Safty SA. Omega-3 polyunsaturated fatty acids in large doses attenuate seizures, cognitive impairment, and hippocampal oxidative DNA damage in young kindled rats. Neurosci Lett. 2014 Oct 11. pii: S0304-3940(14)00806-4.

Grayson DS, Kroenke CD, Neuringer M, Fair DA. Dietary Omega-3 Fatty Acids Modulate Large-Scale Systems Organization in the Rhesus Macaque Brain. J Neurosci. 2014 Feb 5;34(6):2065-74. doi: 10.1523/JNEUROSCI.3038-13.2014. FULL TEXT

Wiesmann M, Kiliaan AJ, Claassen JA. Vascular aspects of cognitive impairment and dementia. J Cereb Blood Flow Metab. 2013 Nov;33(11):1696-706. FULL TEXT

O’Callaghan N, Parletta N, Milte CM et al. Telomere shortening in elderly people with mild cognitive impairment may be attenuated with omega-3 fatty acid supplementation: A randomised controlled pilot study. Nutrition. Available online 3 October 2013.In Press, Accepted Manuscript.

O’Callaghan N, Parletta N, Milte CM et al. Telomere shortening in elderly people with mild cognitive impairment may be attenuated with omega-3 fatty acid supplementation: A randomised controlled pilot study. Nutrition. Available online 3 October 2013.In Press, Accepted Manuscript.

Witte AV, Kerti L, Hermannstädter HM et al. Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults. Cereb Cortex. 2013 Jun 24.

Denis I, Potier B, Vancassel S, Heberden C, Lavialle M. Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. Ageing Res Rev. 2013 Mar;12(2):579-94.

Avramovic N, Dragutinovic V, Krstic D et al. The effects of omega 3 fatty acid supplementation on brain tissue oxidative status in aged wistar rats. Hippokratia. 2012 Jul;16(3):241-5. FULL TEXT

Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology. 2012; 78:241-249. FULL TEXT

Tan ZS, Harris WS, Beiser AS et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012; 78:658-664.

Samieri C, Maillard P, Crivello F, Proust-Lima C, Peuchant E, Helmer C, Amieva H, Allard M, Dartigues JF, Cunnane SC, Mazoyer BM, Barberger-Gateau P. Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe. Neurology. 2012; 79:642-650.

Nilsson A, Radeborg K, Salo I et al. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study. Nutr J 2012;11:99. FULL TEXT

Matesanz N, Park G, McAllister H et al. Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6815-25.

Yurko-Mauro K, McCarthy D, Rom D et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010 Nov;6(6):456-64. doi: 10.1016/j.jalz.2010.01.013.

Zhang F, Yang H, Pan Z et al. Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5601-9. FULL TEXT

Yurko-Mauro K, McCarthy D, Rom D et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010 Nov;6(6):456-64. doi: 10.1016/j.jalz.2010.01.013.

Marszalek JR, Lodish HF. Docosahexaenoic acid, fatty acid-interacting proteins and neural function. Annual Review of Cell and Development Biology 2005; 21: 633-657.

Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging Clin Exp Res 1993; 5: 123-33.

Memoria

Personalidad borderline

Trastorno bipolar

Shakeri J, Khanegi M, Golshani S et al. Effects of Omega-3 Supplement in the Treatment of Patients with Bipolar I Disorder. Int J Prev Med. 2016 May 19;7:77. doi: 10.4103/2008-7802.182734. eCollection 2016. FULL TEXT

McNamara RK, Welge JA. Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disord. 2016 Apr 18. doi: 10.1111/bdi.12386. [Epub ahead of print]

Rosenblat JD, Kakar R, Berk M et al. Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis. Bipolar Disord. 2016 Mar 18. doi: 10.1111/bdi.12373. [Epub ahead of print]

Saunders EF, Reider A, Singh G, Gelenberg AJ, Rapoport SI. Low unesterified:esterified eicosapentaenoic acid (EPA) plasma concentration ratio is associated with bipolar disorder episodes, and omega-3 plasma concentrations are altered by treatment. Bipolar Disord. 2015 Nov;17(7):729-42.

Wozniak J, Faraone SV, Chan J et al. A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study. J Clin Psychiatry. 2015 Nov;76(11):1548-55. doi: 10.4088/JCP.14m09267.

McNamara RK, Jandacek R, Tso P, Blom TJ, Welge JA, Strawn JR, Adler CM, DelBello MP, Strakowski SM. First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine. Psychiatry Res. 2015 Oct 9. pii: S0165-1781(15)30394-2.

Clayton EH, Hanstock TL, Hirneth SJ et al. Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur J Clin Nutr. 2009 Aug;63(8):1037-1040.

Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry. 1999;56:407-12. FULL TEXT

Trastorno de déficit de atención e hiperactividad (TDAH)

Adultos

Niños

Alfven G, Strandvik B. Anti-nociceptive fatty acid patterns differ in children with psychosomatic recurrent abdominal pain and healthy controls. Acta Paediatr. 2016 Feb 29. doi: 10.1111/apa.13381. [Epub ahead of print]

Bos DJ, Oranje B, Veerhoek ES, Van Diepen RM, Weusten JM, Demmelmair H, Koletzko B, de Sain-van der Velden MG, Eilander A, Hoeksma M, Durston S. Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology. 2015 Sep;40(10):2298-306. FULL TEXT

Wu Q, Zhou T, Ma L, Yuan D, Peng Y. Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder. Nutrition. 2015 Jul-Aug;31(7-8):935-40.

Gow RV, Hibbeln JR, Parletta N. Current evidence and future directions for research with omega-3 fatty acids and attention deficit hyperactivity disorder. Curr Opin Clin Nutr Metab Care. 2015 Mar;18(2):133-8.

Milte CM, Parletta N, Buckley JD et al. Increased Erythrocyte Eicosapentaenoic Acid and Docosahexaenoic Acid Are Associated With Improved Attention and Behavior in Children With ADHD in a Randomized Controlled Three-Way Crossover Trial. J Atten Disord. 2013 Nov 8.

Richardson A. Background to the DOLAB Studies: Omega-3 and Child Behaviour and Learning. Omega-3 DHA and Children’s Behaviour and Learning: New Insights from the ‘DOLAB’ Studies. 4 September 2013 - The Royal College of Surgeons, London.

Dervola KS, Roberg BA, Wøien G et al. Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD. Behavioral and Brain Functions 2012;8(56):13 p. FULL TEXT

Bloch MH, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry 2011;50(10):991-1000. FULL TEXT

Gustafsson PA, Birberg-Thornberg U, Duchén K et al. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD. Acta Paediatr. 2010 Oct;99(10):1540-1549.

Johnson M, Ostlund S, Fransson G, Kadesjö B, Gillberg C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J Atten Disord. 2009 Mar;12(5):394-401.

Gow RV, Matsudaira T, Taylor E, Rubia K, Crawford M, Ghebremeskel K, Ibrahimovic A, Vallée-Tourangeau F, Williams LM, Sumich A. Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):151-6.

Sorgi PJ, Hallowell EM, Hutchins HL, Sears B. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behaviour in children with attention deficit hyperactivity disorder. Nutr J. 2007;6:16. FULL TEXT

Burgess JR, Stevens L, Zhang W, Peck L. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am J Clin Nutr. 2000;71(1 Suppl):327-30. FULL TEXT

Stevens LJ, Zentall SS, Deck JL, Abate ML, Watkins BA, Lipp SR, Burgess JR. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr. 1995;62(4):761-8. FULL TEXT

Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr (Philadelphia) 1987; 26(8): 406-11.

Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr (Philadelphia) 1987; 26(8): 406-11.

Trastornos pricóticos

Koola MM, Raines JK, Hamilton RG et al. Can anti-inflammatory medications improve symptoms and reduce mortality in schizophrenia? Curr Psychiatr. 2016 May;15(5):52-57. Epub 2016 Apr 25. FULL TEXT

Kim SW, Jhon M, Kim JM et al. Relationship between Erythrocyte Fatty Acid Composition and Psychopathology in the Vienna Omega-3 Study. PLoS One. 2016 Mar 10;11(3):e0151417. doi: 10.1371/journal.pone.0151417. eCollection 2016. FULL TEXT

Gavzan H, Sayyah M, Sardari S, Babapour V. Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1029-38.

Kokacya MH, Inanir S, Copoglu US, Dokuyucu R, Erbas O. The Antipsychotic Effects of Omega-3 Fatty Acids in Rats. Am J Med Sci. 2015 Sep;350(3):212-7.

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