Estudios

Miscelánea

Ter Borg S, de Groot LC, Mijnarends DM et al. Differences in Nutrient Intake and Biochemical Nutrient Status Between Sarcopenic and Nonsarcopenic Older Adults-Results From the Maastricht Sarcopenia Study. J Am Med Dir Assoc. 2016 Jan 26. pii: S1525-8610(15)00765-3. doi: 10.1016/j.jamda.2015.12.015. [Epub ahead of print] FULL TEXT

Ter Borg S, de Groot LC, Mijnarends DM et al. Differences in Nutrient Intake and Biochemical Nutrient Status Between Sarcopenic and Nonsarcopenic Older Adults-Results From the Maastricht Sarcopenia Study. J Am Med Dir Assoc. 2016 Jan 26. pii: S1525-8610(15)00765-3. doi: 10.1016/j.jamda.2015.12.015. [Epub ahead of print] FULL TEXT

Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015 Jul;102(1):115-22.

Li R, Sabir JS, Baeshen NA, Akoh CC. Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. J Food Sci. 2015 Nov;80(11):H2578-84.

Xiao G, Yuan F, Geng Y, Qiu X, Liu Z, Lu J, Tang L, Zhang Y, Su L. Eicosapentaenoic Acid Enhances Heat Stroke-impaired Intestinal Epithelial Barrier Function in Rats. Shock. 2015 Oct;44(4):348-56.

Crawford MA, Wang Y, Forsyth S, Brenna JT. The European Food Safety Authority recommendation for polyunsaturated fatty acid composition of infant formula overrules breast milk, puts infants at risk, and should be revised. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec;102-103:1-3.

Yurko-Mauro K, Kralovec J, Bailey-Hall E, Smeberg V, Stark JG, Salem N Jr. Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study. Lipids Health Dis. 2015 Sep 2;14:99. FULL TEXT

Sabour H, Norouzi Javidan A, Latifi S, Shidfar F, Heshmat R, Emami Razavi SH, Vafa MR, Larijani B. Omega-3 fatty acids' effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial. J Spinal Cord Med. 2015 Sep;38(5):599-606.

Delfan M, Ebrahim K, Baesi F, Mirakhori Z, Ghalamfarsa G, Bakhshaei P, Saboor-Yaraghi AA, Razavi A, Setayesh M, Yousefi M, Jadidi-Niaragh F. The immunomodulatory effects of fish-oil supplementation in elite paddlers: A pilot randomized double blind placebo-controlled trial. Prostaglandins Leukot Essent Fatty Acids. 2015 Aug;99:35-40.

Ruiz-Lopez N, Stubhaug I, Ipharraguerre I, Rimbach G, Menoyo D. Positional Distribution of Fatty Acids in Triacylglycerols and Phospholipids from Fillets of Atlantic Salmon (Salmo Salar) Fed Vegetable and Fish Oil Blends. Mar Drugs. 2015 Jul 10;13(7):4255-69. FULL TEXT

Delplanque B, Gibson R, Koletzko B, Lapillonne A, Strandvik B. Lipid Quality in Infant Nutrition: Current Knowledge and Future Opportunities. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):8-17.

Betancor MB, Sprague M, Sayanova O, Usher S, Campbell PJ, Napier JA, Caballero MJ, Tocher DR. Evaluation of a high-EPA oil from transgenic Camelina sativa in feeds for Atlantic salmon (Salmo salar L.): Effects on tissue fatty acid composition, histology and gene expression. Aquaculture. 2015 Jul 1;444:1-12. FULL TEXT

Salunke D, Manglekar R, Gadre R, Nene S, Harsulkar AM. Production of polyunsaturated fatty acids in recombinant Lipomyces starkeyi through submerged fermentation. Bioprocess Biosyst Eng. 2015 Jul;38(7):1407-14.

Roy J, Le Guennec JY, Galano JM, Thireau J, Bultel-Poncé V, Demion M, Oger C, Lee JC, Durand T. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs? Biochimie. 2015 Jun 23. pii: S0300-9084(15)00181-9. doi: 10.1016/j.biochi.2015.06.010.

Lewis EJH, Radonic PW, Wolever TMS, Wells GD. 21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo. J Int Soc Sports Nutr. 2015 Jun 18;12:28. FULL TEXT

Smith G, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015 May 20. pii: ajcn105833.

Wagner A, Simon C, Morio B, Dallongeville J, Ruidavets JB, Haas B, Laillet B, Cottel D, Ferrières J, Arveiler D. Omega-3 index levels and associated factors in a middle-aged French population: the MONA LISA-NUT Study. Eur J Clin Nutr. 2015 Apr;69(4):436-41 doi:10.1038/ejcn.2014.219

Ácido alfa-linolénico

Algas

Emulsiones

Shinde RL, Bharkad GP, Devarajan PV. Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: Role of docosahexaenoic acid. Eur J Pharm Biopharm. 2015 Oct;96:363-79.

Manzanares W, Langlois PL. Fish oil containing lipid emulsions in critically ill patients: Critical analysis and future perspectives. Med Intensiva. 2015 Sep 21. pii: S0210-5691(15)00165-5.

Skouroliakou M, Konstantinou D, Agakidis C, Kaliora A, Kalogeropoulos N, Massara P, Antoniadi M, Panagiotakos D, Karagiozoglou-Lampoudi T. Parenteral MCT/ω-3 Polyunsaturated Fatty Acid-Enriched Intravenous Fat Emulsion Is Associated With Cytokine and Fatty Acid Profiles Consistent With Attenuated Inflammatory Response in Preterm Neonates: A Randomized, Double-Blind Clinical Trial. Nutr Clin Pract. 2015 Sep 16.

Linecker M, Limani P, Botea F, Popescu I, Alikhanov R, Efanov M, Kim P, Khatkov I, Raptis DA, Tschuor C, Beck-Schimmer B, Bonvini J, Wirsching A, Kron P, Slankamenac K, Humar B, Graf R, Petrowsky H, Clavien PA. A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven™) on outcome after major liver resection. BMC Gastroenterol. 2015 Aug 14;15:102. FULL TEXT

Goyal A, Sharma V, Upadhyay N, Singh AK, Arora S, Lal D, Sabikhi L. Development of stable flaxseed oil emulsions as a potential delivery system of ω-3 fatty acids. J Food Sci Technol. 2015 Jul;52(7):4256-65.

Trépanier MO, Kwong KM, Domenichiello AF, Chen CT, Bazinet RP, Burnham WM. Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model. Epilepsy Behav. 2015 Jun 30;50:71-76.

Wu GH, Gao J, Ji CY, Pradelli L, Xi QL, Zhuang QL. Cost and effectiveness of omega-3 fatty acid supplementation in Chinese ICU patients receiving parenteral nutrition. Clinicoecon Outcomes Res. 2015 Jun 26;7:369-75. FULL TEXT

Zugasti Murillo A, Petrina Jáuregui E, Elizondo Armendáriz J. Parenteral nutrition-associated liver disease and lipid emulsions. Endocrinol Nutr. 2015 Jun-Jul;62(6):285-9.

Zugasti Murillo A, Petrina Jáuregui E, Elizondo Armendáriz J. Parenteral nutrition-associated liver disease and lipid emulsions. Endocrinol Nutr. 2015 May 13. pii: S1575-0922(15)00094-7. doi: 10.1016/j.endonu.2015.03.008.

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K. Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial. Crit Care. 2015 May 12;19(1):226. doi: 10.1186/s13054-015-0933-6.

Cavazos-Garduño A, Ochoa Flores AA, Serrano-Niño JC, Martínez-Sanchez CE, Beristain CI, García HS. Preparation of betulinic acid nanoemulsions stabilized by ω-3 enriched phosphatidylcholine. Ultrason Sonochem. 2015 May;24:204-13. doi: 10.1016/j.ultsonch.2014.12.007.

Esquerdo VM, Dotto GL, Pinto LA. Preparation of nanoemulsions containing unsaturated fatty acid concentrate-chitosan capsules. J Colloid Interface Sci. 2015 May 1;445:137-42. doi: 10.1016/j.jcis.2014.12.094.

Manzanares W, Langlois PL, Dhaliwal R, Lemieux M, Heyland DK. Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis. Crit Care. 2015 Apr 16;19(1):167. doi: 10.1186/s13054-015-0888-7.

Vestland TL, Jacobsen Ø, Sande SA, Myrset AH, Klaveness J. Compactible powders of omega-3 and β-cyclodextrin. Food Chem. 2015 Oct 15;185:151-8. doi: 10.1016/j.foodchem.2015.03.132. Epub 2015 Apr 4.

Turner JM, Josephson J, Field CJ, Wizzard PR, Ball RO, Pencharz PB, Wales PW. Liver Disease, Systemic Inflammation, and Growth Using a Mixed Parenteral Lipid Emulsion, Containing Soybean Oil, Fish Oil, and Medium Chain Triglycerides, Compared With Soybean Oil in Parenteral Nutrition-Fed Neonatal Piglets. JPEN J Parenter Enteral Nutr. 2015 Apr 2. pii: 0148607115579711.

Divya Erattea, Stafford McKnighta, Thomas R. Gengenbachb, Kim Dowlinga, Colin J. Barrow, Benu P. Adhikarid. Co-encapsulation and characterisation of omega-3 fatty acids and probiotic bacteria in whey protein isolate–gum Arabic complex. Journal of Functional Foods. online 16 February 2015.

Böttcher S, Steinhäuser U, Drusch S. Off-flavour masking of secondary lipid oxidation products by pea dextrin. Food Chem. 2015 Feb 15;169:492-8. doi: 10.1016/j.foodchem.2014.05.006.

Larsen BM, Field CJ, Leong AY, Goonewardene LA, Van Aerde JE, Joffe AR, Clandinin MT. Pretreatment with an intravenous lipid emulsion increases plasma eicosapentanoic acid and downregulates leukotriene b4, procalcitonin, and lymphocyte concentrations after open heart surgery in infants. JPEN J Parenter Enteral Nutr. 2015 Feb;39(2):171-9. doi: 10.1177/0148607113505326. Epub 2013 Oct 11.

Wang B, Vongsvivut J, Adhikari B, Barrow CJ. Microencapsulation of tuna oil fortified with the multiple lipophilic ingredients vitamins A, D3, E, K2, curcumin and coenzyme Q10. Journal of Functional Foods. 2015.

Biagetti C, Vedovelli L, Savini S, Simonato M, D'Ascenzo R, Pompilio A, Cogo PE, Carnielli VP. Double blind exploratory study on de novo lipogenesis in preterm infants on parenteral nutrition with a lipid emulsion containing 10% fish oil. Clin Nutr. 2015 Apr 12. pii: S0261-5614(15)00103-X. doi: 10.1016/j.clnu.2015.04.005.

Enfermedad de células falciformes

Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siciliano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L. Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015 Jul;100(7):870-80. FULL TEXT

Daak AA, Elderdery AY, Elbashir LM, Mariniello K, Mills J, Scarlett G, Elbashir MI, Ghebremeskel K. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease. Blood Cells Mol Dis. 2015 Jun;55(1):48-55. doi: 10.1016/j.bcmd.2015.03.014.

Daak AA, Elderdery AY, Elbashir LM, Mariniello K, Mills J, Scarlett G, Elbashir MI, Ghebremeskel K. Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with homozygous sickle cell disease. Blood Cells Mol Dis. 2015 Jun;55(1):48-55.

Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siliciano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L. Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015 May 1. pii: haematol.2015.124586.

Wandersee NJ, Maciaszek JL, Giger KM, Hanson MS, Zheng S, Guo Y, Mickelson B, Hillery CA, Lykotrafitis G, Low PS, Hogg N. Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. Blood Cells Mol Dis. 2015 Feb;54(2):183-8. doi: 10.1016/j.bcmd.2014.11.004. Epub 2014 Nov 25.

Okpala I, Ibegbulam O, Duru A, Ocheni S, Emodi I, Ikefuna A, Umar G, Asinobi I, Madu A, Okoye A, Nwagha T, Oguonu U, Uamai I, Agwu O, Nonyelu C, Anike U, Agu K, Anigbo C, Chukwura A, Ugwu O, Herrada S. Pilot study of omega-3 fatty acid supplements in sickle cell disease. APMIS. 2011 Jul;119(7):442-8. doi: 10.1111/j.1600-0463.2011.02751.x.

Enfermedad pulmonar obstructiva crónica

Enfermedad renal crónica

Deger SM, Hung AM, Ellis CD et al. High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol. 2016 Jun 8. pii: CJN.04150415. [Epub ahead of print]

Umemoto N, Ishii H, Kamoi D et al. Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis. Atherosclerosis. 2016 Apr 1;249:65-69. doi: 10.1016/j.atherosclerosis.2016.03.037. [Epub ahead of print]

Barden AE, Burke V, Mas E, Beilin LJ, Puddey IB, Watts GF, Irish AB, Mori TA. n-3 fatty acids reduce plasma 20-hydroxyeicosatetraenoic acid and blood pressure in patients with chronic kidney disease. J Hypertens. 2015 Sep;33(9):1947-53.

Viecelli AK, Pascoe E, Polkinghorne KR, Hawley C, Paul-Brent PA, Badve SV, Cass A, Heritier S, Kerr PG, Mori TA, Robertson A, Seong HL, Irish AB; FAVOURED study team. The Omega-3 fatty acids (Fish Oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) study: the updated final trial protocol and rationale of post-initiation trial modifications. BMC Nephrol. 2015 Jun 27;16:89. FULL TEXT

Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M. Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression. Intern Med. 2015;54(18):2377-82. FULL TEXT

Lee SM, An WS. Cardioprotective effects of ? -3 PUFAs in chronic kidney disease. Biomed Res Int. 2013;2013:712949. FULL TEXT

Entorno hospitalario y quirúrgico

Baldursson BT, Kjartansson H, Konrádsdóttir F, Gudnason P, Sigurjonsson GF, Lund SH. Healing Rate and Autoimmune Safety of Full-Thickness Wounds Treated With Fish Skin Acellular Dermal Matrix Versus Porcine Small-Intestine Submucosa: A Noninferiority Study. Int J Low Extrem Wounds. 2015 Mar 9. pii: 1534734615573661.

Basili S, Raparelli V, Napoleone L, Del Ben M, Merli M, Riggio O, Nocella C, Carnevale R, Pignatelli P, Violi F; on behalf of the CALC Group. Polyunsaturated fatty acids balance affects platelet NOX2 activity in patients with liver cirrhosis. Dig Liver Dis. 2014 Apr 1. pii: S1590-8658(14)00274-6.

Myhrstad MC, Ulven SM, Günther CC, Ottestad I, Holden M, Ryeng E, Borge GI, Kohler A, Brønner KW, Thoresen M, Holven KB. Fish oil supplementation induces expression of genes related to cell cycle, endoplasmic reticulum stress and apoptosis in peripheral blood mononuclear cells: a transcriptomic approach. J Intern Med. 2014 Mar 18. doi: 10.1111/joim.12217. [Epub ahead of print]

Kes VB, Cesarik M, Matovina LZ, Zavoreo I, Corić L, Drnasin S, Demarin V. The role of complementary and alternative medicine in therapy of multiple sclerosis. Acta Clin Croat. 2013 Dec;52(4):464-71.

Virtanen JK, Siscovick DS, Lemaitre RN et al. Circulating omega-3 polyunsaturated Fatty acids and subclinical brain abnormalities on MRI in older adults: the cardiovascular health study. J Am Heart Assoc. 2013 Oct 10;2(5):e000305.

Siasos G, Tousoulis D, Oikonomou E et al. Effects of omega-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: a cross over study. Int J Cardiol. 2013 Jun 20;166(2):340-6.

Kurihara T, Jones CN, Yu YM et al. Resolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J. 2013 Jun;27(6):2270-81.

Bohr S, Patel SJ, Sarin D et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen. 2013 Jan-Feb;21(1):35-43.

Wang T, Van KC, Gavitt BJ et al. Effect of fish oil supplementation in a rat model of multiple mild traumatic brain injuries. Restor Neurol Neurosci. 2013 Jan 1;31(5):647-59.

Mozaffarian D, Lemaitre RN, King IB, Song X, Huang H, Sacks FM, Rimm EB, Wang M, Siscovick DS. Plasma phospholipid long-chain omega-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. Ann Intern Med. 2013; 158:515-525.

Hsiao HM, Sapinoro RE, Thatcher TH et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS One. 2013;8(3):e58258.

Tipton KD. Dietary strategies to attenuate muscle loss during recovery from injury. Nestle Nutr Inst Workshop Ser 2013;75:51-61.

Sabbatini M1, Apicella L, Cataldi M, Maresca I, Nastasi A, Vitale S, Memoli B, Postiglione L, Riccio E, Gallo R, Federico S, Guida B. Effects of a diet rich in N-3 polyunsaturated fatty acids on systemic inflammation in renal transplant recipients. J Am Coll Nutr. 2013;32(6):375-83.

Lee SM, An WS. Cardioprotective effects of ? -3 PUFAs in chronic kidney disease. Biomed Res Int. 2013;2013:712949.

Stanley WC, Khairallah RJ, Dabkowski ER. Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):122-6. doi: 10.1097/MCO.0b013e32834fdaf7.

Rius B, López-Vicario C, González-Périz A, Morán-Salvador E, García-Alonso V, Clária J, TitosE. Resolution of inflammation in obesity-induced liver disease. Front Immunol. 2012; 3: 257.

Taha AY, Ciobanu FA, Saxena A, McIntyre Burnham W. Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy. Epilepsy Behav. 2009 Jan;14(1):27-31. Epub 2008 Dec 2.

Curación de heridas

Epilepsia

Glomerulonefritis

Hepático

Li L, Wang B, Yu P et al. Medium and Long Chain Fatty Acids Differentially Modulate Apoptosis and Release of Inflammatory Cytokines in Human Liver Cells. J Food Sci. 2016 Jun;81(6):H1546-52. doi: 10.1111/1750-3841.13321. Epub 2016 May 3.

Valenzuela R, Espinosa A, Llanos P, Hernandez-Rodas MC, Barrera , Vergara D, Romero N, Pérez F, Ruz M, Videla LA. Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil mixture in the liver of mice subjected to high-fat diet. Food Funct. 2015 Oct 16.

Nobili V , Alisi A , Musso G , Scorletti E , Calder PC , Byrne CD. Omega-3 fatty acids: Mechanisms of benefit and therapeutic effects in pediatric and adult NAFLD. Crit Rev Clin Lab Sci. 2015 Oct 14:1-15.

Linecker M, Limani P, Botea F, Popescu I, Alikhanov R, Efanov M, Kim P, Khatkov I, Raptis DA, Tschuor C, Beck-Schimmer B, Bonvini J, Wirsching A, Kron P, Slankamenac K, Humar B, Graf R, Petrowsky H, Clavien PA. A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven™) on outcome after major liver resection. BMC Gastroenterol. 2015 Aug 14;15:102 FULL TEXT

Scorletti E, West AL, Bhatia L, Hoile SP, McCormick KG, Burdge GC, Lillycrop KA, Clough GF, Calder PC, Byrne CD. Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: results from the WELCOME trial. J Hepatol. 2015 Aug 10. pii: S0168-8278(15)00539-5. doi: 10.1016/j.jhep.2015.07.036.

Nishiokada A, Miyoshi M, Fujiwara M, Aoyama-Ishikawa M, Maeshige N, Takahashi M, Hamada Y, Usami Y, Honda M, Arita M, Usami M. Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 weeks in endotoxemic rats using LC-ESI-MS/MS. Clin Nutr. 2015 Aug;34(4):685-93.

Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol. 2015 Jul 15;286(2):102-11.

Janczyk W, Lebensztejn D, Wierzbicka-Rucińska A3, Mazur A, Neuhoff-Murawska J, Matusik P, Socha P. Omega-3 Fatty acids therapy in children with nonalcoholic Fatty liver disease: a randomized controlled trial. J Pediatr. 2015 Jun;166(6):1358-63.e1-3.

Kabel AM, Abd Elmaaboud MA, Albarraq AA. Ameliorative potential of omega 3 fatty acids and HMG-CoA reductase inhibitors on experimentally-induced non-alcoholic steatohepatitis. Prostaglandins Leukot Essent Fatty Acids. 2015 May;96:1-9. doi: 10.1016/j.plefa.2014.12.003.

Janczyk W, Lebensztejn D, Wierzbicka-Rucińska A, Mazur A, Neuhoff-Murawska J, Matusik P, Socha P. Omega-3 Fatty Acids Therapy in Children with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial. J Pediatr. 2015 Mar 11. pii: S0022-3476(15)00103-1. doi: 10.1016/j.jpeds.2015.01.056.

Infertilidad masculina

de Luis DA, Izaola O, Cuellar L et al. Clinical effects of a w3 enhanced powdered nutritional formula in postsurgical ambulatory head and neck cancer patients. Nutr Hosp. 2013 Septiembre-Octubre;28(5):1463-1467.

Terrando N, Gómez-Galán M, Yang T, Carlström M, Gustavsson D, Harding RE, Lindskog M, Eriksson LI. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. FASEB J 2013; May 24.

Marsman HA, de Graaf W, Heger M et al. Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids. Br J Surg. 2013 Apr;100(5):674-83.

Kenchegowda S, He J, Bazan HE. Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):27-31.

Tipton KD. Dietary strategies to attenuate muscle loss during recovery from injury. Nestle Nutr Inst Workshop Ser 2013;75:51-61.

Philipson TJ, Snider JT, Lakdawalla DN et al. Impact of oral nutritional supplementation on hospital outcomes. Am J Manag Care 2013;19(2):121-128.

Safarinejad MR, Safarinejad S. The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility. Asian J Androl 2012;14(4):514-515.

Cortina MS, He J, Li N et al. Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. Arch Ophthalmol. 2012 Jan;130(1):76-83.

Zhu MW, Tang DN, Hou J et al. Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery. Chin Med J (Engl). 2012 Jan;125(2):178-81.

Grau Carmona T, López Martínez J, Vila García B; Metabolism and Nutrition Working Group of the Spanish Society of Intensive Care Medicine and Coronary units. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: respiratory failure. Nutr Hosp. 2011 Nov;26 Suppl 2:37-40.

van der Meij BS, van Bokhorst-de van der Schueren MA, Langius JA et al. n-3 PUFAs in cancer, surgery, and critical care: a systematic review on clinical effects, incorporation, and washout of oral or enteral compared with parenteral supplementation. Am J Clin Nutr. 2011 Nov;94(5):1248-1265.

Klek S, Kulig J, Szczepanik AM, Jedrys J, Kolodziejczyk P. The clinical value of parenteral immunonutrition in surgical patients. Acta Chir Belg 2005;105:175-1791

Mediadores lipídicos pro-resolución especializados

Wang Y, Li R, Chen L, Tan W, Sun Z, Xia H, Li B, Yu Y, Gong J, Tang M, Ji Y, Yuan S, Shanglong Yao, Shang Y. Maresin1 Inhibits Epithelial-to-Mesenchymal Transition in vitro and Attenuates Bleomycin Induced Lung Fibrosis in vivo. Shock. 2015 Nov;44(5):496-502.

Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia D. Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. Crit Care Med. 2015 Oct 27.

Katakura M, Hashimoto M, Inoue T, Mamun AA, Tanabe Y, Arita M, Shido O. Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. PLoS One. 2015 Oct 20;10(10):e0140884. FULL TEXT

Orr SK, Butler KL, Hayden D, Tompkins RG, Serhan CN, Irimia D. Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients. Crit Care Med. 2015 Dec;43(12):2642-2650.

Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K. Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. J Exp Med. 2015 Oct 19;212(11):1921-30.

Kim N, Ramon S, Thatcher TH, Woeller CF, Sime PJ , Phipps RP. Specialized pro-resolving mediators (SPMs) inhibit human B-cell IgE production. Eur J Immunol. 2015 Oct 17. doi: 10.1002/eji.201545673.

Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RP. Resolvins Attenuate Inflammation and Promote Resolution in Cigarette Smoke-Exposed Human Macrophages. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L888-901.

Hiram R, Rizcallah E, Marouan S, Sirois C, Sirois M, Morin C, Fortin S, Rousseau E. Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L776-88.

Arnardottir H, Orr SK, Dalli J, Serhan CN. Human milk proresolving mediators stimulate resolution of acute inflammation. Mucosal Immunol. 2015 Oct 14.

Hsiao HM, Thatcher TH, Colas RA, Serhan CN, Phipps RP, Sime PJ. Resolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol. 2015 Oct 12. pii: S0002-9440(15)00496-4.

Prieto P, Rosales-Mendoza CE, Terrón V, Toledano V, Cuadrado A, López-Collazo E, Bannenberg G, Martín-Sanz P, Fernández-Velasco M, Boscá L. Activation of autophagy in macrophages by pro-resolving lipid mediators. Autophagy. 2015 Oct 3;11(10):1729-44.

Gong J, Liu H, Wu J, Qi H, Wu ZY, Shu HQ, Li HB, Chen L, Wang YX, Li B, Tang M, Ji YD, Yuan SY, Yao SL, Shang Y. Maresin 1 prevents lipopolysaccharide-induced neutrophil survival and accelerates resolution of acute lung injuty. Shock. 2015 Oct;44(4):371-80.

Fiala M, Terrando N, Dalli J. Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Alzheimers Dis. 2015 Sep 9;48(2):293-301.

Herrera BS, Kantarci A, Zarrough A, Hasturk H, Leung KP, Van Dyke TE. LXA4 actions direct fibroblast function and wound closure. Biochem Biophys Res Commun. 2015 Sep 4;464(4):1072-7.

Kang GJ, Lee HJ, Kang YP, Kim EJ, Kim HJ, Byun HJ, Park MK, Cho H, Kwon SW, Lee CH. High-mobility group box 1 suppresses resolvin D1-induced phagocytosis via induction of resolvin D1-inactivating enzyme, 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 2015 Sep;1852(9):1981-8.

Cox Jr R, Phillips O, Fukumoto J, Fukumoto I, Tamarapu Parthasarathy P, Arias S, Cho Y, Lockey RF, Kolliputi N. Aspirin-Triggered Resolvin D1 Treatment Enhances Resolution of Hyperoxic Acute Lung Injury. Am J Respir Cell Mol Biol. 2015 Sep;53(3):422-35.

Cox R Jr, Phillips O, Fukumoto J, Fukumoto I, Parthasarathy PT, Arias S, Cho Y, Lockey RF, Kolliputi N. Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. Am J Respir Cell Mol Biol. 2015 Sep;53(3):422-35.

Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CN. The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. Am J Respir Cell Mol Biol. 2015 Sep;53(3):314-25.

Dalli J, Chiang N, Serhan CN. Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med. 2015 Sep;21(9):1071-5.

Zhang T, Shu HH, Chang L, Ye F, Xu KQ, Huang WQ. Resolvin D1 protects against hepatic ischemia/reperfusion injury in rats. Int Immunopharmacol. 2015 Sep;28(1):322-7.

Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015 Aug 21;4(8). FULL TEXT

Goto T, Urabe D, Masuda K, Isobe, Arita M, Inoue M. Total Synthesis of Four Stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-Dihydroxy-4,7,10,12,16,18-docosahexaenoic Acid and Their Anti-inflammatory Activities. J Org Chem. 2015 Aug 7;80(15):7713-26.

Romano M, Cianci E, Simiele F, Recchiuti A. Lipoxins and aspirin-triggered lipoxins in resolution of inflammation. Eur J Pharmacol. 2015 Aug 5;760:49-63.

McArthur S, Gobbetti T, Kusters DH, Reutelingsperger CP, Flower RJ, Perretti M. Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. J Immunol. 2015 Aug 1;195(3):1139-51. FULL TEXT

Chiang N, Dalli J, Colas RA, Serhan CN. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. J Exp Med. 2015 Jul 27;212(8):1203-17.

Herrera BS, Kantarci A, Zarrough A, Hasturk H, Leung KP, Van Dyke TE. LXA4 actions direct fibroblast function and wound closure. Biochem Biophys Res Commun. 2015 Jul 17.

Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson C. Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Cell Metab. 2015 Jul 7;22(1):125-37.

Nordgren TM, Bauer CD, Heires AJ, Poole JA, Wyatt TA, West WW, Romberger DJ. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Transl Res. 2015 Jul;166(1):57-69.

Harrison JL, Rowe RK, Ellis TW, Yee NS, O'Hara BF, Adelson PD, Lifshitz J. Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. Brain Behav Immun. 2015 Jul;47:131-40.

Karra L, Haworth O, Priluck R, Levy BD, Levi-Schaffer F. Lipoxin B4 promotes the resolution of allergic inflammation in the upper and lower airways of mice. Mucosal Immunol. 2015 Jul;8(4):852-62.

Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M, Halade GV. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. J Mol Cell Cardiol. 2015 Jul;84:24-35.

Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H. Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep. 2015 Jun 11;5:9750. FULL TEXT

Colby JK, Gott KM, Wilder JA, Levy BD. Differences in Lung Cryptococcus neoformans Burden After Infection are Associated with Lipoxin Signaling. Am J Respir Cell Mol Biol. 2015 Jun 3.

Vasconcelos DP, Costa M, Amaral IF, Barbosa MA, Águas AP, Barbosa JN. Development of an immunomodulatory biomaterial: using resolvin D1 to modulate inflammation. Biomaterials. 2015 Jun;53:566-73.

Tsugawa H, Cajka T, Kind T, Ma Y, Higgins B, Ikeda K, Kanazawa M, VanderGheynst J, Fiehn O, Arita M. MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. Nat Methods. 2015 Jun;12(6):523-6. doi: 10.1038/nmeth.3393.

Akagi D, Chen M, Toy R, Chatterjee A, Conte MS. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice. FASEB J. 2015 Jun;29(6):2504-13.

Kendall AC, Pilkington SM, Massey KA, Sassano G, Rhodes LE, Nicolaou A. Distribution of bioactive lipid mediators in human skin. J Invest Dermatol. 2015 Jun;135(6):1510-20.

López-Vicario C, Rius B, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Titos E, Clària J. Pro-resolving mediators produced from EPA and DHA: Overview of the pathways involved and their mechanisms in metabolic syndrome and related liver diseases. Eur J Pharmacol. 2015 May 15.

López-Vicario C, Rius B, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Titos E, Clària J. Pro-resolving mediators produced from EPA and DHA: Overview of the pathways involved and their mechanisms in metabolic syndrome and related liver diseases. Eur J Pharmacol. 2015 May 15. pii: S0014-2999(15)00456-2. doi: 10.1016/j.ejphar.2015.03.092.

Frömel T, Fleming I. Whatever happened to the epoxyeicosatrienoic Acid-like endothelium-derived hyperpolarizing factor? The identification of novel classes of lipid mediators and their role in vascular homeostasis. Antioxid Redox Signal. 2015 May 10;22(14):1273-92.

Tian Y, Zhang Y, Zhang R, Qiao S, Fan J. Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson's disease rat model. Biochem Biophys Res Commun. 2015 May 8;460(3):799-805. doi: 10.1016/j.bbrc.2015.03.109.

Crean D, Godson C. Specialised lipid mediators and their targets. Semin Immunol. 2015 May;27(3):169-76.

Blanchard HC, Taha AY, Rapoport SI, Yuan ZX. Low-dose aspirin (acetylsalicylate) prevents increases in brain PGE2, 15-epi-lipoxin A4 and 8-isoprostane concentrations in 9 month-old HIV-1 transgenic rats, a model for HIV-1 associated neurocognitive disorders. Prostaglandins Leukot Essent Fatty Acids. 2015 May;96:25-30. doi: 10.1016/j.plefa.2015.01.002.

Lastrucci C, Baillif V, Behar A, Al Saati T, Dubourdeau M, Maridonneau-Parini I, Cougoule C. Molecular and cellular profiles of the resolution phase in a damage-associated molecular pattern (DAMP)-mediated peritonitis model and revelation of leukocyte persistence in peritoneal tissues. FASEB J. 2015 May;29(5):1914-29. doi: 10.1096/fj.14-259341.

Block RC, Abdolahi A, Tu X, Georas SN, Brenna JT, Phipps RP, Lawrence P, Mousa SA. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. Prostaglandins Leukot Essent Fatty Acids. 2015 May;96:17-24.

Hasturk H, Abdallah R, Kantarci A, Nguyen D, Giordano N, Hamilton J, Van Dyke TE. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol. 2015 May;35(5):1123-33.

Mas E, Barden A, Burke V, Beilin LJ, Watts GF, Huang RC, Puddey IB, Irish AB, Mori TA. A randomized controlled trial of the effects of n-3 fatty acids on resolvins in chronic kidney disease. Clin Nutr. 2015 Apr 13. pii: S0261-5614(15)00102-8. doi: 10.1016/j.clnu.2015.04.004.

Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M, Halade GV. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. J Mol Cell Cardiol. 2015 Apr 11;84:24-35.

Keeren K, Huang D, Smyl C, Fischer A, Rothe M, Weylandt KH. Effect of Different Omega-6/Omega-3 Polyunsaturated Fatty Acid Ratios on the Formation of Monohydroxylated Fatty Acids in THP-1 Derived Macrophages. Biology (Basel). 2015 Apr 9;4(2):314-26. doi: 10.3390/biology4020314.

Serhan CN, Chiang N, Dalli J. The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015 Apr 6. pii: S1044-5323(15)00012-3. doi: 10.1016/j.smim.2015.03.004.

Zhang X, Yang N, Ai D, Zhu Y. Systematic metabolomic analysis of eicosanoids after omega-3 polyunsaturated Fatty Acid supplementation by a highly specific liquid chromatography-tandem mass spectrometry-based method. J Proteome Res. 2015 Apr 3;14(4):1843-53. doi: 10.1021/pr501200u.

Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta. 2015 Apr;1851(4):397-413. doi: 10.1016/j.bbalip.2014.08.006.

Fiala M, Halder RC, Sagong B, Ross O, Sayre J, Porter V, Bredesen DE. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. FASEB J. 2015 Mar 24. pii: fj.14-264218.

Morin C, Cantin AM, Rousseau É, Sirois M, Sirois C, Rizcallah E, Fortin S. Pro-resolving Action of MAG-DHA in Lung Inflammatory Models Related to Cystic Fibrosis. Am J Respir Cell Mol Biol. 2015 Mar 17.

Orr SK, Colas RA, Dalli J, Chiang N, Serhan CN. Pro-resolving actions of a new Resolvin D1 analog mimetic qualifies as an immunoresolvent. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 13:ajplung.00370.2014. doi: 10.1152/ajplung.00370.2014

Barnig C, Levy BD. Innate immunity is a key factor for the resolution of inflammation in asthma. Eur Respir Rev. 2015 Mar;24(135):141-53.

Dalli J, Ramon S, Norris PC, Colas RA, Serhan CN. Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. FASEB J. 2015 Feb 20. pii: fj.14-268441.

Kasuga K, Suga T, Mano N. Bioanalytical insights into mediator lipidomics. J Pharm Biomed Anal. 2015 Feb 16. pii: S0731-7085(15)00106-5. doi: 10.1016/j.jpba.2015.02.011.

Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BD. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol. 2015 Feb 1;194(3):863-7. doi: 10.4049/jimmunol.1402534.

Keelan JA, Mas E, D'Vaz N, Dunstan JA, Li S, Barden AE, Mark PJ, Waddell BJ, Prescott SL, Mori TA. Effects of maternal n-3 fatty acid supplementation on placental cytokines, pro-resolving lipid mediators and their precursors. Reproduction. 2015 Feb;149(2):171-8. doi: 10.1530/REP-14-0549.

Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N. Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol. 2015 Feb;172(3):910-23.

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